Prevalence of Cryptosporidiosis and Helicobacter Pylori Infection and Their Coinfection among Human Immunodeficiency Virus Positive and Negetive Patients in Adamawa State, Nigeria

Cryptosporidiosis is a public health problem affecting a wide range of vertebrates both domestic animals and humans causing potentially lethal diarrhea in AIDS, it extends from isolated events to epidemic proportions. Helicobacter pylori infection (HPI) is widespread with an estimated 50% of the world population infected (1). The burden of the infection in Africa is high with a reported prevalence of 70.1% (2). Recent studies reported by (3) showed that Nigeria has high load  of H. Pylori infection with the prevalence rate of 87.7% with Northern part of the country having the highest prevalence compare to other regions of the country. The aim of this study was to determine the prevalence of Cryptosporidiosis and H. pylori infection and their co-infection among HIV/AIDS positive and negative patients using three health facilities of Adamawa state. A cross-sectional hospital-based design was adopted for the study. Stool samples were collected from participants and analyzed using standard parasitological and microbiological techniques for the detection of Cryptosporidium oocysts and H. pylori. Relevant clinical data were obtained using structured questionnaires. Data generated were analyzed using descriptive statistics, while inferential analysis was conducted using the chi-square test at a 5% level of significance to test for an association between Cryptosporidiosis and H. pylori infection among HIV/AIDS positive and negative patients. The findings revealed that Helicobacter pylori infection was the most prevalent with 52.3%, followed by Cryptosporidiosis with 47.7%, while co-infection occurred in a notable proportion of participants with 17.4%. Higher prevalence of infections was observed among HIV-positive participants compared to HIV-negative participants. Variations were observed across health facilities, however, most of these differences were not statistically significant.