Determinants of Mpox Infection in Bayelsa State, Nigeria from 1st January, 2017 to 31st May, 2025

Introduction: Mpox is caused by the monkeypox virus ( MPXV ) which is an enveloped double – stranded DNA virus that belong to the Orthopoxvirus genus in the poxviridae family. Sporadic outbreaks of Mpox have been reported in Africa, typically originating from contact with wildlife reserves particularly rodents but outside the Africa region, since early May 2022, more than 3000 cases of Mpox infection have been reported in more than 50 countries across five regions. Despite  several efforts taken to halt the transmission of Mpox infection at global, national and sub national level, outbreaks of Mpox continue to occur especially in Bayelsa state. .The aim of this study was  to assess sociodemographic  determinants of  Mpox  infection  in Bayelsa state, from 2017 to  31st of May, 2025 with specific objectives to determine the geographical distribution of Mpox infection in Bayelsa state and to determine sociodemograhic factors that are significantly associated with Mpox infection  A cross sectional mixed method  was used for  this study. The sample size of the study was 222 and data collected were analyzed using descriptive and inferential statistical methods. The SPSS statistical software version 25 was used to analyze the data. Binary logistic regression analysis was used to determine strength and significant of association between exposure and outcome variables. The result of the study on  Sociodemographic risk factors that are significantly associated with Mpox infection are the young adult with an OR of 2.777 and old adult age group with an OR of 2.997, the occupations that are significantly associated with Mpox are public servants and self employed/private business and urban dwellers.We made some  recommendations which are mass vaccination campaign, sensitization of the public, strengthening the surveillance system and Risk communication.