Comparative Evaluation of Effects of Propofol and Procaine Anaesthesia on Serum Electrolytes and Proteins of Male Wistar Rats

Comparative evaluation of effects of Propofol and procaine on serum electrolytes and proteins of male Wistar rats was studied. A total of 20 male Wistar rats were used for the study and were divided into 4 groups. Group 1 was the control group which received 10ml of distilled water, group 2 received 5mg/kg of procaine, and group 3 received 10mg/kg of propofol while group 4 received both 5mglkg of procaine and 10mg/kg of propofol combined together. After drug administration, blood samples were collected into plain sample bottles for biochemical analysis using automated biochemical analyzer. ANOVA was used as the data analysis method. Results revealed no significant change in sodium, calcium potassium and bicarbonate ions. Estimation of serum proteins revealed no significant change in total protein, albumin and globulin. Conclusively, propofol and procaine anesthesia does not have the potentials to alter serum electrolytes and protein of male Wistar Rats.

Keywords: procaine, propofol, anaesthesia.